(Life Extension) Pregnenolone is a prohormone. It is made directly from cholesterol within the mitochondria of the adrenal glands and, to a lesser degree, the nervous system. Pregnenolone is a precursor to various hormones, such as progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. So it can help the body maintain normal hormone levels, which in turn helps numerous body functions including healthy aging. Do not take if you have breast or prostate cancer, or other hormone-sensitive diseases. 1-4 daily.